ALDARA / IMIQUIMOD TRIGGERS HSV HERPES OUTBREAK

 


HSV  herpes simplex virus  cytokine induced inflammation prostaglandin  ctcl

 

 

A 74-year old Caucasian woman was being treated for cutaneous T-cell lymphoma (CTCL).    The Aldara/imiquimod she was using in her treatment of this incurable CTCL disease triggered the activation and out-break of herpes simplex virus (HSV), a known side-effect of Aldara.

 

Title

Topical Imiquimod Therapy for Cutaneous T-Cell Lymphoma 

Posted 10/29/03

 Excerpts  from Article:

 Adverse skin reaction included (among others) scarring as a consequence of cytokine induced inflammation……..

 …imiquimod has been shown to increase levels of prostaglandin E2 , which has been associated with the activation of herpes simplex virus (HSV).

Imiquimod therapy has been associated with recurrences of HSV in patients with a history of facial HSV.

  

Author(s):  Jennifer H. Do, MA, MD - Susan S. McLaughlin, MA, MD - Anthony A. Gaspari, MD

 Source:       Medscape – WEBMD posted 10/29/2003

 

 

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